Could a Gene Be Affecting Your Postpartum Recovery? What You Should Know About the MTHFR Gene

If you're navigating postpartum and feeling more tired, foggy, or emotionally low than you expected, you're not alone — and it's not in your head. One possible factor behind these symptoms that many parents have never heard of is the MTHFR gene mutation. Understanding this common genetic variation can be a powerful step toward reclaiming your energy and emotional balance.
At Lamb & Latch Doula Services, we believe in nurturing the whole person — body, mind, and spirit. That includes helping you explore root causes that may impact your recovery after birth. As someone who has this gene, I know I suffered some of the consequences of not being able to process folate. Let’s take a closer look at what the MTHFR gene is, how it might be affecting you, and what you can do about it.

What is the MTHFR Gene?
MTHFR stands for methylenetetrahydrofolate reductase — a gene that plays a key role in how your body processes folic acid (vitamin B9). It helps convert folic acid into methylfolate, the active form your body uses for:
• Brain function and mood regulation
• DNA repair and detoxification
• Energy metabolism
• Hormonal balance
Roughly 40% of the population has a mutation in this gene that reduces its function. That means even if you’re taking a standard prenatal or multivitamin, your body might not be absorbing what it needs.

Why It Matters in the Postpartum Period
The postpartum phase is a time of massive physical, emotional, and neurological changes. You’re healing from birth, adjusting to new sleep patterns, breastfeeding (if you choose to), and managing hormonal shifts.
If your body isn’t converting folic acid properly, it can lead to low folate levels — and that can affect your:
• Mood
• Energy
• Healing
• Mental clarity
Research has linked MTHFR gene mutations to:
• Postpartum depression
• Increased anxiety
• Fatigue
• Brain fog
• Poor wound healing

How to Get Tested
Testing for the MTHFR mutation is easier than you might think:
• Ask your provider for an MTHFR gene test — usually a simple blood test or cheek swab
• The test checks for two common mutations: C677T and A1298C
• Ask about homocysteine testing, which gives insight into how your body uses folate

What to Do if You Have It
If you find out you have the MTHFR mutation, don’t panic — there are supportive steps you can take.
Instead of standard folic acid, your body may benefit from methylated nutrients, including:
• Methylfolate (active B9)
• Methylcobalamin (active B12)
• P5P (active B6)
Look for supplements labeled "methylated" or try a formula like Methylation Complete. You can also increase your intake of natural folate from foods like:
• Leafy greens (spinach, kale, romaine)
• Avocados
• Asparagus
• Lentils and chickpeas
• Beets

Folic Acid vs. Methylfolate: Why It Matters
Most prenatal vitamins and fortified foods use synthetic folic acid, which people with MTHFR mutations may not convert efficiently. This means you could still be functionally deficient — even with supplementation — unless you're using the active form, methylfolate.

Is There a Link Between MTHFR and Postpartum Depression?
Emerging studies suggest that women with MTHFR gene mutations may have a greater risk of postpartum depression. When your brain doesn’t receive enough methylfolate, the production of mood-regulating neurotransmitters like serotonin and dopamine can suffer.
Supporting your body with the right nutrients can make a real difference in how you feel emotionally after birth.

Final Thoughts from Lamb & Latch Doula Services
Your postpartum journey deserves as much attention and support as your birth. If you’re struggling with symptoms that don’t feel “normal” — persistent sadness, anxiety, fatigue, or overwhelm — consider asking your provider about MTHFR testing.
Nourishing your body with the right form of folate might be the missing puzzle piece in your recovery.
You were never meant to do this alone.
Whether it’s emotional support, resources, or help navigating postpartum wellness, we’re here for you.

With love and faith,
Sydney
Founder of Lamb & Latch Doula Services
DONA International Doula, Aspiring IBCLC, Breastfeeding Advocate

Lamb & Latch Doula Services
Serving the Winston Salem Triad, NC area with compassionate, whole-person care